Sean Simonini
Neuroscience and Biotechnology Policy
Working on regenerative therapies for patients suffering from neurodegenerative diseases such as ALS and conditions such as Traumatic Brain Injuries.
Research
Conducting drug discovery for neuroprotective compounds by building automated analysis pipelines.
Leading a project to identify genetic perturbations that enhance cell therapy/neuronal replacement efficacy.
Researching the underlying effects of aging in the onset of ALS and identifying potential therapeutic candidates.
Characterizing the effect of Sarm1 ablation in ameliorating traumatic brain injury and ALS phenotypes, with an emphasis on TDP-43 mislocalization.
Developed pipelines to predict brain-region specific gene expression patterns in patients with Alzheimer's Disease and made comparisons to normal aging to identify canonical brain aging expression patterns (also see Biomarkers of Aging presentation 2024).
Examined GWAS data of patients with and without Chronic Traumatic Encephalopathy (CTE) to identify potentially resilient genes as well as gene expression patterns that tell us more about the progression of the disease.
Community Building
VP of Neuroscience and Policy (Board Member) - working to connect aging biology researchers and the larger community with decision makers to ensure everyone can live healthier, for longer.
Managing Director of the Inside: Aging Series - hosting global leaders in aging biology on monthly webinars to educate students, trainees, investors, and the general public about what aging biology is (and what it isn't!) as well as how to get involved.
Member of the inaugural cohort of the Time Fellowship, working to expand aging biology investment; currently mentoring members of Cohort 2!
Latest from Substack
Observations and ideas for how to build life from the bottom-up.
An honest examination of what I am doing, and why I am here.
Get In Touch
Feel free to reach out if you're interested in my research, community initiatives, or potential collaborations.
seanrsimonini {at} gmail {dot} com
Substack
seansimonini.substack.com